Key Takeaways

  • What Is the DHPP Vaccine for Dogs?
  • What Viruses Does the DHPP Vaccine Protect Against?
  • Do All Dogs Need the DHPP Vaccine?
  • Dogs & Puppies
  • Dog Health Care
  • Dog Preventative Care
JoAnna Pendergrass, DVM head shot

JoAnna Pendergrass, DVM, is a veterinarian and freelance medical writer in Atlanta, Ga. She is the founder and owner of JPen Communications, a medical communications company that specializes in educating pet parents about pet health and pet care. Dr. Pendergrass is passionate about closing the gap between what the veterinarian says and what the pet parent understands. Through her writing, she empowers pet parents with the medical information they need to make good health decisions for their pets. She is a member of the American Medical Writers Association and the BlackDVM Network. In her spare time, Dr. Pendergrass enjoys spending time with her husband, reading, and being a bona fide science nerd.

  • What is the DHPP Vaccine for Dogs?
  • What Viruses Does the DHPP Vaccine Protect Against?
  • Do All Dogs Need the DHPP Vaccine?
  • How Effective Is the DHPP Vaccine?
  • Side Effects
  • Vaccine Schedule
  • Cost
Photo: Kalim / Adobe Stock
Photo: Kalim / Adobe Stock

The DHPP vaccine for dogs, also known as the five-in-one vaccine, protects dogs from multiple diseases at a time with just one shot. Many of us know getting vaccinated as kids wasn't exactly the most pleasant experience for many of us. But those vaccinations protected us from serious, preventable diseases that could have made us quite sick.

Vaccinations are as crucial for our dogs as they are for us. Ideally, vaccinations start in puppyhood to continue providing disease protection after protective antibodies from mom's breastmilk fade from a puppy's system.

What Is the DHPP Vaccine for Dogs?

The DHPP vaccine protects dogs against five highly contagious viral diseases that cause severe illness and may be fatal: distemper, canine adenovirus-1 (CAV-1), canine adenovirus-2 (CAV-2), parainfluenza, and parvovirus. Its name is an acronym for those diseases (adenovirus can sometimes lead to hepatitis). Other abbreviations for the vaccine are DA2PP and DAPP.

The vaccine contains weakened versions of the viruses and stimulates the immune system to produce antibodies without causing actual illness.

What Viruses Does the DHPP Vaccine Protect Against?

Here is a brief rundown of the five viruses in the DHPP vaccine:

  • Distemper: The distemper virus is spread via respiratory droplets and contact with contaminated surfaces, such as food bowls. It affects multiple body systems, including the respiratory and digestive systems. Dogs with distemper have symptoms such as vomiting and diarrhea. Distemper, if left untreated, is rapidly fatal, especially in puppies and older dogs with weak immune systems.
  • CAV-1: CAV-1 causes infectious canine hepatitis, which is progressive and rapidly fatal. It is spread through the urine and feces and primarily targets the liver, potentially causing permanent organ damage.
  • CAV-2: CAV-2 is less severe than the other viruses in the DHPP vaccine. It is associated with kennel cough, causing such symptoms as a hacking cough, fever, and nasal discharge. The virus is spread through respiratory droplets.
  • Parainfluenza: Parainfluenza is spread through respiratory droplets and causes flu-like symptoms (coughing, fever, nasal discharge). However, it is not related to the canine influenza virus.
  • Parvovirus: The parvovirus attacks the delicate lining of the digestive system, causing vomiting, foul-smelling and bloody diarrhea, and life-threatening dehydration from fluid loss. Puppies are especially susceptible to parvo, which is fatal if left untreated. The virus is hardy and stubbornly resistant to disinfectants.

Do All Dogs Need the DHPP Vaccine?

Yes! The DHPP vaccine is a core vaccine, meaning it is recommended for all dogs, regardless of age, health condition, or lifestyle. It is especially critical for puppies and dogs with weakened immune systems.

How Effective Is the DHPP Vaccine for Dogs?

Studies have demonstrated that the DHPP vaccine remains protective for approximately three to four years, with a 90% level of protection.

Side Effects for Dogs

All vaccines can cause side effects, which are frequently mild and go away within one to two days of the vaccination. These mild side effects include:

  • Pain and swelling at the injection site
  • Lethargy
  • Decreased appetite
  • Mild fever

Serious side effects are rare and indicate an allergic reaction requiring immediate medical attention. If your dog experiences any of the side effects listed below, contact your veterinarian immediately.

  • Facial swelling
  • Difficulty breathing
  • Hives
  • Vomiting
  • Collapse
  • Diarrhea
  • Itching

DHPP Vaccine Schedule for Dogs and Puppies

The American Animal Hospital Association (AAHA) publishes vaccination guidelines for dogs and cats. Here is the AAHA-recommended DHPP vaccination schedule for initial doses:

  • First vaccination at 6 weeks of age
  • Sequential doses every two to four weeks until 16 weeks of age

Dogs (older than 16 weeks of age):

  • One or two doses

A booster is given one year after the initial vaccination series, and then every three years after that.

Before giving the vaccine, your veterinarian will examine your dog to ensure they are healthy. Sick dogs should not be vaccinated because their immune system will not be able to respond appropriately to the vaccine.

How Much Does the DHPP Vaccine Cost?

The cost of the DHPP vaccine depends on several factors, including where you live. Fortunately, as a combination vaccine, the DHPP vaccine is less expensive than vaccinating for each of the five diseases individually.

The DHPP vaccine cost can range from about $40 to $100. Pet insurance can help defray the cost. Also, some veterinary practices offer wellness programs that include the cost of vaccinations and there are pet organizations that have low-cost vaccination clinics for pet owners.

The DHPP vaccine provides crucial, life-saving disease protection for dogs. Keeping your dog up-to-date on this vaccine will help them live a long, happy life, right by your side.

  1. Vaccination Failures in Dogs. VCA Animal Hospitals.
  2. Vaccinations for Your Pet. American Society for the Prevention of Cruelty to Animals.
  3. Abdelmagid OY, Larson L, Payne L, Tubbs A, Wasmoen T, Schultz R. Evaluation of the efficacy and duration of immunity of a canine combination vaccine against virulent parvovirus, infectious canine hepatitis virus, and distemper virus experimental challenges. Vet Ther. 2004;5(3):173-186.
  4. Vaccinations. American Veterinary Medical Association.
  5. AAHA Canine Vaccination Guidelines. American Animal Hospital Association.

Vaccination Failures in Dogs. VCA Animal Hospitals.

Vaccinations for Your Pet. American Society for the Prevention of Cruelty to Animals.

Abdelmagid OY, Larson L, Payne L, Tubbs A, Wasmoen T, Schultz R. Evaluation of the efficacy and duration of immunity of a canine combination vaccine against virulent parvovirus, infectious canine hepatitis virus, and distemper virus experimental challenges. Vet Ther. 2004;5(3):173-186.

Vaccinations. American Veterinary Medical Association.

AAHA Canine Vaccination Guidelines. American Animal Hospital Association.